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under line: lab members

*corresponding author



Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.
Arimura Y, Ikura M, Fujita R, Noda M, Kobayashi W, Horikoshi N, Sun J, Shi L, Kusakabe M, Harata M, Ohkawa Y, Tashiro S, Kimura H, Ikura T, Kurumizaka H
Nucleic acids research 46(19) 10007-10018 2018年7月

Actin polymerization is activated by terahertz irradiation.
Yamazaki S*, Harata M*, Idehara T, Konagaya K, Yokoyama G, Hoshina H, Ogawa Y* (*corresponding authors)
Scientific reports 8(1) 9990 2018年7月

Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, Harata M, Ikura M, Ikura T, Kanaar R, Tashiro S
eLife 7 e32222 2018年5月

SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites.
Fukuto A, Ikura M, Ikura T, Sun J, Horikoshi Y, Shima H, Igarashi K, Kusakabe M, Harata M, Horikoshi N, Kurumizaka H, Kiuchi Y, Tashiro S
Nucleus (Austin, Tex.) 9(1) 87-94 2018年1月

Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.
Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB
The EMBO journal 36(15) 2263-2279 2017年8月

Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases.
Takahashi D, Orihara Y, Kitagawa S, Kusakabe M, Shintani T, Oma Y, Harata M
Bioscience, biotechnology, and biochemistry 81(8) 1557-1560 2017年8月

Actin Family Proteins in the Human INO80 Chromatin Remodeling Complex Exhibit Functional Roles in the Induction of Heme Oxygenase-1 with Hemin.
Takahashi Y, Murakami H, Akiyama Y, Katoh Y, Oma Y, Nishijima H, Shibahara KI, Igarashi K, Harata M
Frontiers in genetics 8 17 2017年

Nuclear F-actin enhances the transcriptional activity of β-catenin by increasing its nuclear localization and binding to chromatin.
Yamazaki S, Yamamoto K, de Lanerolle P, Harata M
Histochemistry and cell biology 145(4) 389-399 2016年4月

Genetic complementation analysis showed distinct contributions of the N-terminal tail of H2A.Z to epigenetic regulations.
Kusakabe M, Oku H, Matsuda R, Hori T, Muto A, Igarashi K, Fukagawa T, Harata M
Genes to cells : devoted to molecular & cellular mechanisms 21(2) 122-135 2016年2月

[Roles of actin family proteins in functional organization of chromatin and the nucleus].
Harata M, Yamazaki S, Oma Y
Seikagaku. The Journal of Japanese Biochemical Society 87(5) 629-632 2015年10月

The actin family protein ARP6 contributes to the structure and the function of the nucleolus.
Kitamura H, Matsumori H, Kalendova A, Hozak P, Goldberg IG, Nakao M, Saitoh N, Harata M
Biochemical and biophysical research communications 464(2) 554-560 2015年8月

Contribution of nuclear actin to transcription regulation.
Yamazaki S, Yamamoto K, Harata M
Genomics data 4 127-129 2015年6月

The linker histone in Saccharomyces cerevisiae interacts with actin-related protein 4 and both regulate chromatin structure and cellular morphology.
Georgieva M, Staneva D, Uzunova K, Efremov T, Balashev K, Harata M, Miloshev G
The international journal of biochemistry & cell biology 59 182-192 2015年2月

Nuclear actin activates human transcription factor genes including the OCT4 gene.
Yamazaki S, Yamamoto K, Tokunaga M, Sakata-Sogawa K, Harata M
Bioscience, biotechnology, and biochemistry 79(2) 242-246 2015年

SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.
Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM
Molecular cell 55(4) 626-639 2014年8月

Nuclear actin filaments recruit cofilin and actin-related protein 3, and their formation is connected with a mitotic block.
Kalendová A, Kalasová I, Yamazaki S, Uličná L, Harata M, Hozák P
Histochemistry and cell biology 142(2) 139-152 2014年8月

Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2.
Nishibuchi I, Suzuki H, Kinomura A, Sun J, Liu NA, Horikoshi Y, Shima H, Kusakabe M, Harata M, Fukagawa T, Ikura T, Ishida T, Nagata Y, Tashiro S
International journal of radiation oncology, biology, physics 89(4) 736-744 2014年7月

DNA binding properties of the actin-related protein Arp8 and its role in DNA repair.
Osakabe A, Takahashi Y, Murakami H, Otawa K, Tachiwana H, Oma Y, Nishijima H, Shibahara KI, Kurumizaka H, Harata M
PloS one 9(10) e108354 2014年

Improvement of the transformation efficiency of Sacchaaromyces cerevisiae by altering carbon sources in pre-culture.
Konishi T, Harata M
Bioscience, biotechnology, and biochemistry 78(6) 1090-1093 2014年

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.
Horikoshi N, Sato K, Shimada K, Arimura Y, Osakabe A, Tachiwana H, Hayashi-Takanaka Y, Iwasaki W, Kagawa W, Harata M, Kimura H, Kurumizaka H
Acta crystallographica. Section D, Biological crystallography 69(Pt 12) 2431-2439 2013年12月

The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei.
Maruyama EO, Hori T, Tanabe H, Kitamura H, Matsuda R, Tone S, Hozak P, Habermann FA, von Hase J, Cremer C, Fukagawa T, Harata M
Journal of cell science 125(Pt 16) 3739-3743 2012年8月

Actin-related proteins localized in the nucleus: from discovery to novel roles in nuclear organization.
Oma Y, Harata M
Nucleus (Austin, Tex.) 2(1) 38-46 2011年1月

ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.
Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, Ikura T, Suzuki H, Mizutani S, Kanaar R, Tashiro S
PloS one 5(10) e13554 2010年10月

Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant.
Matsuda R, Hori T, Kitamura H, Takeuchi K, Fukagawa T, Harata M
Nucleic acids research 38(13) 4263-4273 2010年7月

Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.
Yoshida T, Shimada K, Oma Y, Kalck V, Akimura K, Taddei A, Iwahashi H, Kugou K, Ohta K, Gasser SM, Harata M
PLoS genetics 6(4) e1000910 2010年4月

Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4.
Kumeta M, Yoshimura SH, Harata M, Takeyasu K
Journal of cell science 123(Pt 7) 1020-1030 2010年4月

The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair.
Kitayama K, Kamo M, Oma Y, Matsuda R, Uchida T, Ikura T, Tashiro S, Ohyama T, Winsor B, Harata M
Experimental cell research 315(2) 206-217 2009年1月

Involvement of actin-related protein Arp6 in organization of chromosomes.
Ohfuchi Maruyama E, Harata M
Advances in chromosome sciences 3 26-28 2009年

Cooperation of nuclear actin and myosin families: an approach with antibodies. 
Kitamura H, Ohfuchi Maruyama E, Matsuda R, Harata M
Advances in Chromosome Sciences 3 169-170 2009年

The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization.
Georgieva M, Harata M, Miloshev G
Journal of cellular biochemistry 104(1) 59-67 2008年5月

Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.
Shimada K, Oma Y, Schleker T, Kugou K, Ohta K, Harata M*, Gasser SM* (corresponding authors)
Current biology : CB 18(8) 566-575 2008年4月

The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment.
Aoyama N, Oka A, Kitayama K, Kurumizaka H, Harata M
Experimental cell research 314(4) 859-868 2008年2月

Actin-related protein Arp4 functions in kinetochore assembly.
Ogiwara H, Ui A, Kawashima S, Kugou K, Onoda F, Iwahashi H, Harata M, Ohta K, Enomoto T, Seki M
Nucleic acids research 35(9) 3109-3117 2007年5月

The INO80 complex is required for damage-induced recombination.
Kawashima S, Ogiwara H, Tada S, Harata M, Wintersberger U, Enomoto T, Seki M
Biochemical and biophysical research communications 355(3) 835-841 2007年4月

Harata M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51(14 Suppl) 1943-1949 2006年11月

Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains, lipid rafts, in human polymorphonuclear leukocytes.
Nishiyama A, Kaneko J, Harata M, Kamio Y
Bioscience, biotechnology, and biochemistry 70(6) 1300-1307 2006年6月

[Nuclear structure: its molecular basis and dynamics].
Harata M, Kitayama K, Oma Y
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51(6 Suppl) 591-599 2006年5月

Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1.
Ohfuchi E, Kato M, Sasaki M, Sugimoto K, Oma Y, Harata M
European journal of cell biology 85(5) 411-421 2006年5月

Nuclear actin-related proteins involved in the organization of euchromatin and heterochromatin
Harata Masahiko, Ohfuchi Eri, Oma Yukako
DNA Structure, Chromatin and Gene Expression, 2006  181-191 2006年

The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin-modulating complexes.
Sunada R, Görzer I, Oma Y, Yoshida T, Suka N, Wintersberger U, Harata M
Yeast (Chichester, England) 22(10) 753-768 2005年7月

Analysis of human hArp5 and hIno80, possible components of a novel chromatin remodeling complex
Kitayama Kumiko, Winsor Barbara, Harata Masahiko

Analysis of subcellular localization of mouse LIM domains-containing protein 1 (Limd1)
Hidema Shizu, Inoue Rho, Harata Masahiko, Nishimori Katsuhiko

[Multiple roles of the actin family in the cell nucleus].
Harata M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 49(4) 543-552 2004年3月

Molecular cloning and expression analysis of vitellogenin in scallop, Patinopecten yessoensis (Bivalvia, Mollusca).
Osada M, Harata M, Kishida M, Kijima A
Molecular reproduction and development 67(3) 273-281 2004年3月

Roles of actin-related proteins in complexes involved in the modulation of chromatin structure
Masahiko Harata, Takahito Yoshida, Eri Ohfuchi
Nippon Nogeikagaku Kaishi 78 652-655 2004年1月

Fission yeast Arp6 is required for telomere silencing, but functions independently of Swi6.
Ueno M, Murase T, Kibe T, Ohashi N, Tomita K, Murakami Y, Uritani M, Ushimaru T, Harata M
Nucleic acids research 32(2) 736-741 2004年

The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP.
Oma Y, Nishimori K, Harata M
Biochemical and biophysical research communications 301(2) 521-528 2003年2月

Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.
Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M
Biochemical and biophysical research communications 299(2) 328-334 2002年11月

Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm.
Ohfuchi E, Nishimori K, Harata M
Bioscience, biotechnology, and biochemistry 66(8) 1740-1743 2002年8月

Correlation between chromatin association and transcriptional regulation for the Act3p/Arp4 nuclear actin-related protein of Saccharomyces cerevisiae.
Harata M, Zhang Y, Stillman DJ, Matsui D, Oma Y, Nishimori K, Mochizuki R
Nucleic acids research 30(8) 1743-1750 2002年4月

Z and W chromosomes of chickens: studies on their gene functions in sex determination and sex differentiation.
Mizuno S, Kunita R, Nakabayashi O, Kuroda Y, Arai N, Harata M, Ogawa A, Itoh Y, Teranishi M, Hori T
Cytogenetic and genome research 99(1-4) 236-244 2002年

Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin
Masahiko Harata, Katsuhiko Nishimori, Shunsuke Hatta
Biochimica et Biophysica Acta - Gene Structure and Expression 1522 130-133 2001年12月

The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.
Suzuki H, Seki M, Kobayashi T, Kawabe Yi, Kaneko H, Kondo N, Harata M, Mizuno S, Masuko T, Enomoto T
Biochemical and biophysical research communications 286(2) 322-327 2001年8月

Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA.
Niimi A, Suka N, Harata M, Kikuchi A, Mizuno S
Chromosoma 110(2) 102-114 2001年5月

Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin.
Kato M, Sasaki M, Mizuno S, Harata M
Gene 268(1-2) 133-140 2001年5月

Absence of Z-chromosome inactivation for five genes in male chickens.
Kuroda Y, Arai N, Arita M, Teranishi M, Hori T, Harata M, Mizuno S
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 9(6) 457-468 2001年

Multiple actin-related proteins of Saccharomyces cerevisiae are present in the nucleus.
Harata M, Oma Y, Tabuchi T, Zhang Y, Stillman DJ, Mizuno S
Journal of biochemistry 128(4) 665-671 2000年10月

The nuclear actin-related protein of Saccharomyces cerevisiae, Act3p/Arp4, interacts with core histones.
Harata M, Oma Y, Mizuno S, Jiang YW, Stillman DJ, Wintersberger U
Molecular biology of the cell 10(8) 2595-2605 1999年8月

Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.
Harata M, Mochizuki R, Mizuno S
Bioscience, biotechnology, and biochemistry 63(5) 917-923 1999年5月

Actin-family proteins localized in the nucleus
M. Harata
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 44 1796-1803 1999年1月

A nuclear matrix-associated high molecular mass nuclear antigen, HMNA, of chicken and marked decrease of its immunoreactivity during the progression of S phase.
Shimada K, Harata M, Mizuno S
Journal of cell science 110 ( Pt 24) 3031-3041 1997年12月

Purification and nucleic-acid-binding properties of a Saccharomyces cerevisiae protein involved in the control of ploidy
Viktoria Weber, Viktoria Weber, Andreas Wernitznig, Gudrun Hager, Masahiko Harata, Peter Frank, Ulrike Wintersberger
European Journal of Biochemistry 249 309-317 1997年1月

The actin-related protein Act3p of Saccharomyces cerevisiae is located in the nucleus
Viktoria Weber, Masahiko Harata, Hanns Hauser, Ulrike Wintersberger, Ulrike Wintersberger
Molecular Biology of the Cell 6 1263-1270 1995年1月

An essential gene of Saccharomyces cerevisiae coding for an actin-related protein.
Harata M, Karwan A, Wintersberger U
Proceedings of the National Academy of Sciences of the United States of America 91(17) 8258-8262 1994年8月

Erratum: An essential gene of Saccharomyces cerevisiae coding for an actin-related protein (Proceedings of the National Academy of Sciences of the United States of America (August 16, 1994) 91:17 (8258-8262))
M. Harata, A. Karwan, U. Wintersberger
Proceedings of the National Academy of Sciences of the United States of America 91 10757 1994年1月

W-heterochromatin of chicken; its unusual DNA components, late replication, and chromatin structure.
Suka N, Shinohara Y, Saitoh Y, Saitoh H, Ohtomo K, Harata M, Shpigelman E, Mizuno S
Genetica 88(2-3) 93-105 1993年

Presence of female-specific bent-repetitive DNA sequences in the genomes of turkey and pheasant and their interactions with W-protein of chicken.
Saitoh H, Harata M, Mizuno S
Chromosoma 98(4) 250-258 1989年10月

Purification and characterization of W-protein. A DNA-binding protein showing high affinity for the W chromosome-specific repetitive DNA sequences of chicken.
Harata M, Ouchi K, Ohata S, Kikuchi A, Mizuno S
The Journal of biological chemistry 263(27) 13952-13961 1988年9月

[Chromatin-level analysis of regulation of gene expression].
Harata M, Mizuno S
Radioisotopes 37(4) 243-253 1988年4月


Harata, M.

Functional Interactions between actin, ARPs and chromatin.

ASCB-EMBO 2018 Meeting, San Diego Convention Center, San Diego, USA, Sep 4, 2018



Harata, M.

Cross-talk of histone and actin families affect chromosome dynamics in mitotic and interphase. 

22nd International Chromosome Conference

City Conference Center (KCC), Prague, Czech Republic, Sep 4, 2018



Harata, M.

Roles of histone- and actin-families in the organization of chromatin and the cell nucleus.

1st München-Japan Mini Symposium“Chromatin Structure and Function”

Munich, Germany.



Harata, M.

Roles of actin and actin-related proteins in chromatin and nuclear organization.

25th Wilhelm Bernhard Workshop, Nizhniy Novgorod, Russia 



Harata, M.

Roles of actin and actin-related proteins in chromatin and nuclear organization.

Nuclear actin in the regulation of transcription and nuclear structure, 近畿大学生物理工学部, 26 Jan, 2017



Harata, M.

Modulating gene functions for immunity and susceptibility to diseases: Towards epigenetic.

Lorentz Center Workshop “Innate Immunity of Crops, Livestock and Fish: The Dawn of Agricultural Immunology”, Lorentz Center, Sep 19, 2016



Harata, M.

Involvement of SUMO-targeted ubiquitin ligase in the establishment of damage dependent sister chromatid cohesion.

 ICY2016, 淡路夢舞台国際会議場, Sep 12, 2016



Harata, M.

H2A.Z and actin family proteins in functional chromatin organization.

Colorado Chromatin Meeting, Colorado, USA, Aug 8, 2016



Harata, M. "Contribution of nuclear actin and Arps to functional organization of the nucleus and chromatin", Institute for Protein Research (IRP) Seminar "Nuclear organization and actin-dependent mechanisms in genome stability", Osaka, Japan



Harata, M. “Nuclear actin and ARPs involved in the functional organization of chromatin.”, The 2014 SCBB/IFCB Meeting, Philadelphia, USA, December 6)



23rd Wilhelm Bernhard Workshop on the cell nucleus (Debrecen, Hungary)

Harata, M.

“Actin family proteins involved in the functional organization of the nucleus”



Wenner-Gren Foundations International Symposium “Actin and actin-associated proteins from gene to polysomes” (Stockholm, Sweden)

Yoshida, T., Oma, Y., Kitamura, H., Shimada, K., Hozak, P., Gasser, S., Harata, M.

“Roles of actin-related proteins in chromatin function and nuclear organization”



52nd Symposium of the Society for Histochemistry (Prague, Czech Republic)

Harata, M.

“Roles of actin-related proteins in nuclear organization and genome function”



Chromosome Dynamics and Genome Stability (Villars, Switzerland)

Yoshida T, Shimada K, Oma Y, Kugou K, Ohta K, Hori T, Fukagawa T, Gasser S, Harata M.

“Actin-related proteins functional organization of chromatin”